This study seeks to describe the state of the hospitals in Mississippi in terms of the computerized physician order entry (CPOE) scores in relation to their overall performance rankings, safety standards, mortality rates from treatable serious complications, as well as the racial composition and the median household income of the city or the town whether the hospital is located. A secondary goal of this study is to determine whether clusters exist among these hospitals in terms of these characteristics.Data is obtained from the 2015 Leapfrog Survey, HealthInsights, and the 2010 U.S. census. Descriptive statistics are used to describe the state of the hospitals in Mississippi in terms of CPOE scores, as well as performance rankings and safety standards in relation to the demographic and socioeconomic characteristics of the city or the town whether the hospital is located. Two-step clustering within SPSS is used to segment hospitals based on the above mentioned characteristics.There is a great variation in terms of CPOE scores among hospitals in Mississippi. Most hospitals in Mississippi have a relatively well functioning CPOE system (the scores range from 65 to 100%). Hospitals with low CPOE functioning scores tend to have low safety grades and tend to be located in low income areas.Strategies to promote usage of the CPOE systems should be continued. Priority should be given to hospitals characterized by low performance rankings and low safety standards that are located in located in areas that are either predominantly black or in areas with low median incomes.