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The ob gene product, leptin, is known to be an important circulating signal for regulation of food intake and body weight. We report here that peripherally applied leptin increased interleukin-1 receptor antagonist (IL-1ra) transcripts in the hypothalamus. Interestingly, we observed leptin-induced increase in IL-1ra transcripts not only in the hypothalamus but also in other brain regions such as the...
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