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Activin, Nodal, and Vg1, members of the transforming growth factor β (TGFβ) superfamily, transduce signal through type I receptors ALK4 or ALK7 and play important roles in mesoderm induction and patterning during vertebrate embryogenesis. However, the timing and magnitude of the ALK4/ALK7-mediated maternal TGFβ signals are not clear. SB-431542 is identified as an inhibitor of the ALK4/ALK5/ALK7-mediated...
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