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The positive element (PE) (−69 to −98 bp) within the 5′-proximal region of the CYP2B1/B2 gene (+1 to −179 bp) of rat liver is essential for phenobarbitone (PB) response and gives a single major complex with the rat liver cytosol in gel shift analysis. This complex corresponds to complex I (top) of the three complexes given by the nuclear extracts. PB treatment of rats leads to a decrease in complex...
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