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We have established that differing effects of α1-adrenergic receptor (AR) subtypes on cell proliferation are due to differential coupling to the Gs/cAMP pathway; thus, both α1A- and α1B-ARs couple to Gs, while α1D-AR does not. To identify the region responsible for this difference in subtype-specific Gs coupling, we constructed a series of chimeric and a set of point-mutated human α1A- and α1D-ARs,...
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