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Aims: New Zealand obese (NZO) mice exhibit a polygenic syndrome of obesity, insulin resistance, and hypercholesterolemia that resembles the human metabolic syndrome. This study was performed in order to locate genes responsible for elevated serum cholesterol and to compare their effects under a standard and high fat diet.Methods: A backcross population of NZO with SJL mice (NZOxF1(SJLxNZO)) was generated...
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