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Leptin increases human α 1 (I) collagen mRNA and type I collagen production and enhances hepatic fibrosis in animal models of hepatic fibrosis. These effects of leptin on fibrogenesis may be mediated by TGFβ1, since leptin increases the TGFβ type II receptor and augments the effect of TGFβ1 on collagen production by stellate cells. In this study, leptin increased the activity of the human...
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