A mathematical model for oxygen transport in the systemic capillary and the surrounding tissue is described. The model takes into account the molecular diffusion in both axial and radial directions in the capillary and tissue, the convective effect of the blood, and the saturation of haemoglobin with oxygen in the blood. The first order metabolic consumption rate of O 2 in the tissue is considered. The nonlinear O 2 dissociation curve (ODC) is approximated by a linear function to simulate the conditions of hyperbaric environment. Its slope is determined by evaluating the derivative of ODC at the arterial PO 2 . The resulting system of partial differential equations is solved analytically by the method of eigenfunction expansion. It is shown that O 2 is transported in the first one-fifth part of the tissue by diffusion (radial and axial), while, in the remaining part of the tissue, radial diffusion is stabilized. The accumulation of O 2 in the tissue is found to be larger with the first order metabolic rate in comparison to the zero order metabolic rate.