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Receptor distribution patterns of neurotransmitters and distinct functional fields of the human brain appear to be tightly connected with respect to their topological allocation along the cerebral cortex. There is, however, considerable lack of human data directly demonstrating this association in vivo. Here, we assessed the relationship between the distribution of the major inhibitory serotonergic...
We performed full modeling analysis of 5-HT 1A –[ 18 F]MPPF interactions using the β-microprobe (βP) and a YAP-(S)PET scanner. Sixteen Wistar rats were used for βP (n=5) and YAP-(S)PET (n=5) acquisitions and metabolite studies (n=6). Time–concentration curves were obtained in the hippocampus, raphe dorsalis, frontal cortex and cerebellum, using three injections of [ 18 F]MPPF...
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