An efficient approach for acoustic topology optimization to minimize the radiated sound power from a vibrating structure is described. The topology optimization is implemented by modifying the local stiffness at discrete locations on the surface of the structure. The radiated sound power level from the structure is directly chosen as the objective function to be minimized. A sensitivity analysis is then implemented to further optimize the layout of the locations of the modified local stiffness. To speed up the computational process, the radiated sound power is computed based on mapped acoustic radiation modes. To demonstrate the acoustic topology optimization using mapped acoustic radiation modes, the radiated sound power of a compressor housing is examined. Based on results from the numerical model, the local stiffness of a compressor housing was experimentally modified. Good agreement in sound power reduction obtained both numerically and experimentally was observed for the overall trend for the sound power levels as a function of one-third octave frequency bands.