Ten MHz AT-cut quartz crystals were modified with a number of polymers and lipids to develop highly sensitive odorant sensors. Among the polymers tested, nylon exhibited the most stable sensor response. After optimization of the vapor flow rate, frequency shifts in response to alcohols were measured. A nylon-coated crystal modified with phosphatidylcholine exhibited greater frequency shifts compared with those obtained from the crystal modified with phosphatidylcholine only. Enhanced frequency shifts in response to alcohols were observed when nylon-coated quartz crystals were modified with three sensors were shown to have sensitivity of the same order as the human sense of smell, as measured using standard odorants for olfactometry in Japan.