For the production of therapy-relevant radionuclides 193m Pt (T 1/2 =4.33d) and 195m Pt (T 1/2 =4.03d) with a high specific activity, the 192 Os(α,n) 195m Pt and 192 Os(α,3n) 193m Pt nuclear reactions were investigated for the first time from their respective thresholds up to 28MeV. Thin samples of enriched 192 Os were prepared by electrodeposition on Ni, and the conventional stacked-foil technique was used for cross-section measurements. The calculated thick target yields were found to be 0.013MBq/μAh for the 192 Os(α,n) 195m Pt reaction in the energy range of E α =24→18MeV, and 0.25MBq/μAh for the 192 Os(α,3n) 193m Pt reaction in the energy range of E α =28→24MeV. The two radionuclides could not be detected in the interactions of 3 He particles with 192 Os. A production method involving high-current α-particle irradiation of enriched 192 Os and efficient chemical separation of radioplatinum was developed. Batch yields of about 1MBq 195m Pt and 8.7MBq 193m Pt were achieved. Compared to the reactor production these batch yields are very low, but the 192 Os(α,n) 195m Pt and 192 Os(α,3n) 193m Pt reactions are superior with respect to the specific activity of the products which is higher by two orders of magnitude.