This study examined how the United States’ National Oceanic and Atmospheric Administration (NOAA) has begun to implement and change its management strategy towards one of an ecosystem approach to management (EAM). In 2005, surveys were conducted with NOAA scientists and resource managers in nine NOAA programs in eight geographic regions across the United States. We quantitatively examined temporal and spatial trends in NOAA's EAM project implementation. Through a qualitative analysis of the data, we identified important lessons learned, best practices, and challenges of NOAA EAM projects. A content analysis identified three of the most frequently provided “success strategies” and include: (1) encouraging collaborations, (2) utilizing multidisciplinary approaches, and (3) identifying common priorities among constituents. We conclude with recommendations for initiatives that NOAA, and others interested in EAM, can undertake to facilitate further ecosystem management opportunities.