Electrodermal activity is a frequently measured physiological response in various applications. It is also being increasingly used in clinical applications. Numerous published papers report results of skin conductance measurements in absolute values, but few are concerned with the quality of results. This paper describes a procedure for metrological evaluation of skin conductance measurement. Three commercial devices for measuring skin conductance were calibrated by comparison with a precision digital ohmmeter used as a reference. Combined measurement uncertainty of skin conductance meters was calculated by means of uncertainty of reference instrument and uncertainties due to measurement repeatability, reproducibility, resolution and environmental condition. Additionally, a procedure for evaluation of the effect of electrode displacement and electrode gel was shown. A model of finger skin conductance profile was build. Measurement uncertainty analysis showed that contributions due to resolution and sensitivity of the measuring device, usually obtained from specifications, are negligible when compared to uncertainty of measuring method. Our results indicate that measurement uncertainty does not meet target uncertainty requirements for certain applications.