This work investigates the modification of the precipitate microstructure induced by laser surface treatments in an AA7449 aluminium alloy in T7651 temper. Microhardness maps in the cross-section below the laser lines, as well as maps of the precipitate size and volume fraction obtained by Small-Angle X-ray Scattering, show that a significant precipitate dissolution and coarsening has been induced by the laser treatment. Integrated modelling is carried out to quantify this effect, including a thermal finite element model, a size class precipitation model and a precipitation hardening model. The precipitation model is calibrated using separate reversion experiments, and then coupled to the thermal and mechanical models, allowing a quantitative description of the modification of the microstructure.