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18 F-fluoro-2-deoxy-glucose (FDG) uptake on PET scan is a prognostic factor for outcome in NSCLC. We investigated changes in FDG uptake during fractionated radiotherapy in relation to metabolic response with the ultimate aim to adapt treatment according to early response.Twenty-three patients, medically inoperable or with advanced NSCLC, underwent four repeated PET-CT scans before, during and...
Local recurrence rates are high in patients with locally advanced NSCLC treated with 60 to 66Gy in 2Gy fractions. It is hypothesised that boosting volumes with high SUV on the pre-treatment FDG-PET scan potentially increases local control while maintaining acceptable toxicity levels. We compared two approaches: threshold-based dose painting by contours (DPBC) with voxel-based dose painting by numbers...
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