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Purpose: A detailed analysis was undertaken of some of the factors influencing the estimate of the labelling index (LI). Materials and methods: Thirty-three human rectal carcinomas were studied for their proliferative activity as measured by the fraction of cells labelled with a single injection of IdUrd 1-8 h before surgical resection. Adjacent specimens were stained both for histological examination...
Background: In recent years T pot (potential doubling time) has been measured before treatment in human tumors in an attempt to estimate the proliferation taking place during a course of irradiation. T pot is defined as T s /LI, where T s is the duration of DNA synthesis and LI is the labeling index (proportion of cells synthesizing DNA). T s...
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