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The technique of 32 P-postlabeling, which was introduced in 1982 for the analysis of DNA adducts, has long been the method of choice for in vivo studies because of its high sensitivity as it requires only <10μg DNA to achieve the detection of 1 adduct in 10 10 normal bases. 32 P-postlabeling has therefore been utilized in numerous human and animal studies of DNA adduct formation...
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