Volatile abundances in Jupiter-family Comet 81P/Wild 2 were measured on four dates in February and March 2010 using high-dispersion (λΔλ∼2.5×10 4 ) infrared spectroscopy with NIRSPEC at the W.M. Keck Observatory. H 2 O was detected on all dates, including measurements on UT March 29 of lines from the ν 2 +ν 3 −ν 2 hot-band not previously targeted in comets. C 2 H 6 and HCN were detected on three dates, and CH 3 OH was detected on one date. Tentative detections or upper-limits are reported for CH 3 OH on other dates, as well as for C 2 H 2 , H 2 CO, and NH 3 . Abundances of all species relative to H 2 O are in the typical range with the exception of CH 3 OH, which is depleted compared to other comets. Gas production was significantly higher in late February than in late March. Rotational temperatures were determined for H 2 O on UT February 22 and 23 and found to be about 30–40K. The spatial distributions of H 2 O, C 2 H 6 , and CH 3 OH are all symmetric and similar to the spatial distribution of the dust continuum. H 2 O abundances from this work are compared to other measurements from both the 1997 and 2010 apparitions. There is no clear evidence of a change in overall gas productivity between the two apparitions within measurement accuracy. Abundances of C 2 H 2 , C 2 H 6 , HCN and NH 3 are consistent with these species being the primary parents of C 2 , CN, NH and NH 2 as measured at optical wavelengths. Although optically classified as carbon-chain depleted, Wild 2 appears more chemically similar in parent volatile chemistry to carbon-chain typical comets; however, we note that in the small sample of Jupiter-family comets measured to date, each comet is chemically distinct.