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Growing understanding of the molecular characteristics of breast cancer is raising the possibility of ultimately delivering therapies that are tailored to the tumour biology of the individual patient. Agents that are currently being evaluated in metastatic breast cancer, irrespective of specific markers such as human epidermal growth factor receptor-2 (HER2) or oestrogen receptor, include the novel...
Since their introduction in the 1960s, anthracyclines such as doxorubicin have attained a central place in the management of a number of solid tumours and haematological malignancies. Anthracycline-based regimens constitute a standard of care in patients with metastatic breast cancer; anthracycline monotherapy compares favourably with taxanes alone, while combinations of anthracyclines and taxanes...
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