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Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours of the digestive tract, although their incidence is low. Management of GIST patients has evolved rapidly following discovery of the role of constitutively activated KIT tyrosine kinase in GIST oncogenesis. Elucidation of the oncogenic mechanism for GIST formed the basis for immunohistochemical diagnosis of GIST as well...
Gastrointestinal stromal tumours (GISTs) are rare mesenchymal malignancies of the gastrointestinal (GI) tract that are a distinct disease entity based on their molecular pathogenesis, immunohistochemical staining, and responsiveness to targeted therapy. The annual incidence of GIST is 11 to 15 cases per million in studies based on Caucasian populations, with GISTs detected at autopsy and those with...
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