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Metastatic bone pain is a significant cause of morbidity in patients with advanced cancer and greatly reduces quality of life. Standard palliative treatments such as opioids may not provide effective relief of metastatic bone pain, particularly acute breakthrough pain, without unacceptable side effects at the high doses required. A mouse model of metastatic bone pain has been developed in which tumor...
Bone pain is a considerable problem for patients with bone metastases from various primary tumors. In this introduction to the Supplement, various data on metastatic bone pain are summarized and available treatment options are briefly introduced.
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