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Angiogenesis is essential for tumour growth, progression and metastasis. Vascular endothelial growth factor (VEGF) is a key angiogenic mediator, and has been shown preclinically to play multiple roles in the development and maintenance of abnormal tumour vasculature, while playing a limited role in adults. VEGF is thus an attractive therapeutic target. Bevacizumab is a humanised anti-VEGF monoclonal...
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