The pursuit of efficient schemes for recognition of physiologically and environmentally important analytes has led to extensive development in the field of supramolecular chemistry. Among various analytes, anions play a fundamental role in many biological processes. However, designing of functional chemosensors for recognition of anions is a major challenge owing to different parameters such as larger size and varying geometries. This review is focused on the development of chemosensors containing NH-binding sites for application in anion sensing and discusses the variation in selectivity as a consequence of structural modification. The mechanism of action for recognition of different anions has also been provided.