A remotely controlled compact system for the production of 6.5 h 8 2 m Rb, a potential substitute for generator-produced 1.3 min 8 2 Rb in myocardial blood flow studies, has been developed. The method utilizes the 8 2 Kr(p,n) 8 2 m Rb process on 90% enriched 8 2 Kr gas. Target development and other technological aspects relevant to the safe handling and recovery of the enriched gas are described. The product 8 2 m Rb activity, deposited on the inner walls of the target, is efficiently isolated by introducing steam in several successive cycles, the total activity being concentrated in about 7 mL of water. The high-current production yield of 8 2 m Rb over the energy range of E p = 14.5 → 10 MeV amounts to about 370 MBq (10 mCi)/μAh, i.e. about 90% of the theoretical value. The only radionuclidic impurity present was 8 3 Rb (T 1 2 = 86.2 days) at a level of 0.04% of 8 2 m Rb. The target system described is very versatile and can also be employed for production of other medically important radionuclides (e.g. 8 1 Rb- 8 1 m Kr generator, 8 3 Sr, etc.) using enriched gases as target materials.