Nanoparticles of titanium oxides have been fabricated by ablating a Ti target with pulsed CO 2 -laser deposition in Ar-diluted oxygen environments. The pulse energy and repetition rate of the CO 2 laser (wavelength 10.6μm) are 0.44J/cm 2 per pulse and 50Hz, respectively. During the focused laser irradiates the Ti target, Ar and O 2 gases are supplied into the irradiation chamber. The gas pressure is varied in a range of 1x10 3 to 1x10 5 Pa. The flow rates of Ar and O 2 gases are adjusted in ranges of 75-83 and 3.3-8.3cm 3 /s, respectively. Above 3x10 4 Pa, the laser irradiation creates nanosized spherical particles of titanium dioxide. The nanospheres are characterized by transmission electron microscopy (TEM) to be of the anatase type. Each nanoparticle consists of a single crystal or single-crystalline domains. The particle size slightly increased with increasing the gas pressure, irrespective of the flow rate. The results demonstrate that nanoparticles of anatase TiO 2 are created by the reactive pulsed laser deposition (PLD).