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We employed multi-electrode array recording to evaluate the influence of NMDA receptors (NMDAR) on spike-timing dynamics in prefrontal networks of monkeys as they performed a cognitive control task measuring specific deficits in schizophrenia. Systemic, periodic administration of an NMDAR antagonist (phencyclidine) reduced the prevalence and strength of synchronous (0-lag) spike correlation in simultaneously...
All primates communicate. To dissect the neural circuits of social communication, we used fMRI to map non-human primate brain regions for social perception, second-person (interactive) social cognition, and orofacial movement generation. Face perception, second-person cognition, and face motor networks were largely non-overlapping and acted as distinct functional units rather than an integrated feedforward-processing...
The cerebral cortex in mammals contains a mosaic of cortical areas that differ in function, architecture, connectivity, and/or topographic organization. A combination of local connectivity (within-area microcircuitry) and long-distance (between-area) connectivity enables each area to perform a unique set of computations. Some areas also have characteristic within-area mesoscale organization, reflecting...
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