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Access to substituted thiapyrrolizidinones and fused pyridones using the domino N-acyliminium-thionium equilibrium/1,3-dipolar cycloaddition/desulfurization cyclization cascade
Substituted thiapyrrolizidinones and fused pyridones, and quinolizinones were reported efficaciously from suitable thioamides in yields ranging from 30% to 65%. The reaction proceeded in a one-pot procedure as cascade process by the intramolecular 1,3-dipolar cycloaddition of thioisomünchnones followed by desulfurization of the adducts. During these investigations, the mechanistic aspects of the process were also discussed.
Laboratoire de Chimie, URCOM, EA 3221, UFR des Sciences & Techniques de l'Université du Havre, B.P: 540, 25 rue Philippe Lebon, F-76058 Le Havre Cedex, France
Laboratoire de Chimie, URCOM, EA 3221, UFR des Sciences & Techniques de l'Université du Havre, B.P: 540, 25 rue Philippe Lebon, F-76058 Le Havre Cedex, France