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We simultaneously monitored changes of intracellular free Ca 2+ concentration ([Ca 2+ ] i ) following different light stimuli from different inner retinal neurons of the turtle retina slice preparation. [Ca 2+ ] i increased with an increase of the light stimulus intensity. Some of the cells also showed color opponent Ca 2+ signals. 2-Amino-4-phosphonobutyric acid (APB) blocked in particular [Ca 2+ ] i increases and picrotoxin enhanced the observed [Ca 2+ ] i changes. These data support the idea that the observed [Ca 2+ ] i changes result from light stimulation and subsequent retinal processing. Similar Ca 2+ signals were observed when the release of Ca 2+ from internal stores was blocked with caffeine and thapsigargin. These results indicate that retinal Ca 2+ signals evoked by light stimulation depend to a large extent on voltage-dependent Ca 2+ influx and might therefore reflect signal processing.