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Behavioral research revealed that object vision is impaired in amblyopia. Nevertheless, neurophysiological research in humans has focused on the amblyopic effects at the earliest stage of visual cortical processing, leaving the question of later, object-specific neural processing deficits unexplored. By measuring event-related potentials (ERPs) to foveal face stimuli we characterized the amblyopic...
The frontal lobe and hippocampal regions are critically involved in memory processing, yet there are limited data providing the timing information that identifies the nature and specific roles of these regions in memory tasks. The present study investigated event-related neural activity using magnetoencephalography (MEG) with a visual working memory (WM) paradigm. Results showed prefrontal and hippocampal...
Some previous studies in brain-damaged patients suggested that neural systems in the left temporal lobe might be crucial in the production and comprehension of nouns, while analogous systems in posterior frontal cortical areas might be involved in the production and comprehension of verbs. We assessed performance on neuropsychological tasks of production and comprehension of nouns and action-verbs...
We studied visuospatial performance and obtained brain perfusion scintigraphy in 27 patients with posterior cortical atrophy (PCA) and 24 healthy controls, with two aims: (1) to determine inter-hemispheric perfusion imbalances underlying signs of spatial neglect and (2) to establish the functional substrates of patients’ performance on distinct visuospatial tasks (line bisection and target cancellation)...
Humans share implicit preferences for cross-modal mappings (e.g., low pitch sounds are preferentially paired with darker colours). Individuals with synaesthesia experience cross-modal mappings to a conscious degree (e.g., they may see colours when they hear sounds). The neonatal synaesthesia hypothesis claims that all humans may be born with this explicit cross-modal perception, which dies out in...
Gilles de la Tourette syndrome (GTS) is characterized by abnormal movements (tics) often associated with behavioural disorders. Neuropathological data from GTS patients have suggested that aberrant activation of distinct striatal functional territories could produce a large spectrum of GTS symptoms. In a monkey model, injections of GABA-antagonist into the striatum enabled us to produce tic-like movements,...
Language and action systems are functionally coupled in the brain as demonstrated by converging evidence using Functional magnetic resonance imaging (fMRI), electroencephalography (EEG), transcranial magnetic stimulation (TMS), and lesion studies. In particular, this coupling has been demonstrated using the action-sentence compatibility effect (ACE) in which motor activity and language interact. The...
Impaired auditory sensitivity to amplitude rise time (ART) has been suggested to be a primary deficit in developmental dyslexia. The present study investigates whether impaired ART-sensitivity at a pre-reading age precedes and predicts later emerging reading problems in a sample of Dutch children. An oddball paradigm, with a deviant that differed from the standard stimulus in ART, was administered...
Self-handicaps are obstacles created (or claimed) by individuals in anticipation of failure. Despite the vast amount of psychological research on self-handicapping tendency, the neural mechanisms underlying individual differences in self-handicapping tendency in young and healthy subjects are unknown. We used voxel-based morphometry (VBM) and a questionnaire to measure individual self-handicapping...
The aim of this study was to test the effect and specificity of a novel, compensatory eye movement training therapy designed to improve visual search performance in patients with homonymous visual field defects.Seven patients with chronic homonymous visual field defects and six healthy control subjects were tested. All subjects completed the single training period (300 trials). Subjects were assessed...
Sensory/functional accounts of semantic memory organization emphasize that object representations in the brain reflect the modalities involved in object knowledge acquisition. The present study aimed to elucidate the impact of different types of object-related sensorimotor experience on the neural representations of novel objects. Sixteen subjects engaged in an object matching task while their brain...
Voxel-based morphometry (VBM) studies demonstrate grey matter volume (GMV) deficits in schizophrenia. This method is also applied for detecting associations between specific psychotic symptoms and brain structure, such as auditory verbal hallucinations (AVHs). However, due to differing methodological approaches, the available findings are inconsistent and difficult to integrate.We used a novel voxel-based...
Autism spectrum disorder (ASD) has long been associated with an inability to experience wholes without full attention to the constituent parts. A zoom-out attentional dysfunction might be partially responsible for this perceptual integration deficit in ASD. In the present study, the efficiency of attentional focusing mechanisms was investigated in children affected by ASD. We measured response latencies...
Schizophrenia is considered a brain disease with a quite heterogeneous clinical presentation. Studies in schizophrenia have yielded a wide array of correlations between structural and functional brain changes and clinical and cognitive symptoms. Reductions of grey matter volume (GMV) in the prefrontal and temporal cortex have been described which are crucial for the development of positive and negative...
Homonymous visual field disorders (HVFD) are frequent and disabling consequences of acquired brain injury, particularly in older age. Their rehabilitation is therefore of great importance. Compensatory oculomotor therapy has been found to be effective in improving the associated functional impairments in reading and visual exploration. But older age is commonly considered to adversely affect practice-dependent...
Previous studies have reported a hemispheric asymmetry in processing dominant (e.g., paper) and subordinate (e.g., farmer) associations of ambiguous words (pen). Here we applied sham and anodal Transcranial Direct Current Stimulation (tDCS) over Wernicke’s area and its right homologue to test whether we can modulate the selective hemispheric expertise in processing lexical ambiguity. Ambiguous prime...
Shakespeare made extensive use of the functional shift (FS), a rhetorical device involving a change in the grammatical status of words, e.g., using nouns as verbs. Previous work using event-related brain potentials showed how FS triggers a surprise effect inviting mental re-evaluation, seemingly independent of semantic processing. Here, we used functional magnetic resonance imaging to investigate...
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