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The profound decrease in serum dihydrotestosterone observed with the dual 5α-reductase inhibitor dutasteride makes it an attractive agent for prostate cancer therapy. To our knowledge we compared for the first time the antitumor effect of dutasteride with that of the specific 5α-reductase-1 inhibitor MK386 and the specific 5α-reductase-2 inhibitor finasteride in human prostate primary cultures.Biochemical...
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