Introduction: Patients with acromegaly often develop lipid abnormalities. No consistent abnormalities of cholesterol have been observed but hypertriglyceridemia occurs in 19-44% of acromegalic patients.Objective: The aim of this study was to investigate the type of lipid abnormalities in acromegalic patients and the effectiveness of therapy on lipid levels.Methods and Materials: We studied 16 patients (9 female and 7 male) whose age ranged 30-65 yrs. 13 patients had active and 3 non active acromegaly. One patient had diabetes mellitus at the time of diagnosis. The mean values of body weight was 80 ± 4 kg (m ± SD) and remained unchanged through the study. All patients were followed-up from 1987 to date.Patients were divided into four groups according to the serum levels of lipids before treatment. Group I (6 patients) had normal values of lipids (37%), Group II (3 patients) had o hypercholesterolemia only (12.8%), Group III (5 patients) had hypertriglyceridemia and hypercholesterolemia (31%) Kα1 Group IV (2 patients) had elevated triglycerides only. (12.5%). Serum 6H, total cholesterol, triglycerides and HDL-ch levels were determined in all patients before, 6, 12 and 24 months after treatment. The treatment for acromegaly consisted of surgical resection (transphenoidal adenomatectony) followed by medical therapy with somatostatin analogues.The results for the total number of patients are summarized in the table (mean SD). Data were analysed by ANOVA After two years of treatment we observed:(1) No significant variation on total cholesterol, triglycerides and HDL-ch levels (table)(2) Significant decrease on GH levels in all four groups.(3) Lipid levels had become normal in 80%, 66%, 40% and 100% of each group (I, II, III, IV) respectively.Association between GH values and lipid levels was not significant (unpaired T-test).Conclusion: A significant number of patients with acromegaly had normal values of lipids at the time of diagnosis. Of those with lipid abnormalities the commonest dyslipidemia observed in our patients was combined hyperlipidemia. Our results show that therapy intervention had better influence on triglycerides values.6 of 10 patients with lipid abnormalities after treatment normalized the lipid profile.