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Purpose: Inflammation and connective tissue hyperplasia are believed to be important etiological factors in cholesteatoma pathogenesis. Previous work has shown that topically applied hyaluronic acid can reduce connective tissue proliferation in healing wounds and accelerate healing of tympanic membrane perforations. This study was undertaken to determine whether the anti proliferative effect of hyaluronic...
Purpose: The histopathological characteristics of middle ear cholesteatoma are hyperproliferation and differentiation of the epithelium and accompanying destruction of the bones. We directed our attention to interleukin 1a (IL-let) and demonstrated localization of IL-1a in the epidermis of cholesteatoma. In addition, a comparative study was made of the relationship of IL-1a with the developmental...
Background: Intraoperative injury to the external branch of the superior laryngeal nerve (EBSLN) can result in significant postoperative voice problems. This injury can be avoided by intraoperative nerve identification. The EBSLN has a close anatomic relationship with the superior thyroid pedicle. According to a previous anatomic classification, the type 2b nerve, which crosses the vessels below the...
Purpose: The MUC2 gene encodes the core protein of a mucin expressed in the intestine and lower airway. The purpose of this study is to examine if the MUC2 gene is expressed in the nose and maxillary sinus.Materials and Methods: A Northern blot analysis and reverse transcription-polymerase chain reaction (RT-PCR) were performed. For the Northern blot analysis, RNAs were extracted from maxillary mucosae...
Purpose: The first mutation associated with nonsyndromic deafness has recently been identified in pedigrees with susceptibility to aminoglycoside ototoxicity and in a large Arab-Israeli pedigree. The mutation is maternally transmitted, and is a nucleotide substitution in the mitochondrial 12S ribosomal RNA gene. A different sequence change, in the mitochondrial tRNA Ser(U ...
Purpose: This study was performed to determine the contribution of the posterior semi-circular canal to the vestibulo-ocular responses (VOR) from caloric stimulation of the labyrinth.Materials and Methods: Seven consecutive patients with disabling benign paroxysmal positional vertigo, which was treated with singular neurectomy, were tested before and after surgery with bithermal stimulation of the...
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