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l-Arginine is one of the precursor amino acids of polyamine biosynthesis in most living organisms including Leishmania parasites. l-Arginine is enzymatically hydrolyzed by arginase producing l-ornithine and urea. In Leishmania spp. and other trypanosomatids a single gene encoding arginase has been described. The product of this gene is compartmentalized in glycosomes and is the main source of l-ornithine...
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