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Effector mechanisms responsible for providing protective immunity against Plasmodium vivax (Pv) infection were examined in Aotus monkeys vaccinated with two Pv Merozoite Surface Protein-1 (PvMSP-1) recombinant polypeptides that had previously been shown to protect vaccines against parasite challenge. Vaccine efficacy was reproducible in this trial, showing that one out of the five monkeys immunised...
Vaccines are a key contributor to public health, especially in developing countries. Despite numerous demonstrations of the cost-effectiveness of immunisation, vaccines spending accounted for only 1.7% of the total pharmaceutical market in 2002, when UNICEF estimated that 34 million children were not reached by routine immunisation, most of them in developing countries.Several international organizations...
This study aimed to conduct quantitative and qualitative analyses of anonymous data from an immunisation hotline call centre over equal periods in 1999 and 2003. Transcripts for all telephone calls in two periods were analysed using thematic and descriptive statistical analyses and significance testing of comparisons made between data from the two periods. Caller numbers increased from 1010 in 1999...
This report presents the findings from a series of 20 surveys carried out between 1991 and 2001. The main objectives of the research were to:•obtain information on mothers’ knowledge of immunisation;•obtain information on mothers’ attitudes towards immunisation;•obtain information on mothers’ experience of immunisation services;•monitor the recall and interpretation of NHS Immunisation Information...
We aimed to determine factors associated with successful vaccination coverage and development of infection in high-risk infants born to hepatitis B infected women. Immunisation of 860/932 (92%) of babies was started within 48h of birth and three doses of vaccination completed for 794/921 (86%). Only 543 (58%) infants were tested and 26 (4.9%) were found to have evidence of current infection. Delayed...
Certain toll-like receptor (TLR) agonists, e.g. CpG DNA, can be used as potent vaccine ‘adjuvants’. It is known that some sequences of single stranded (ss) RNA stimulate proinflammatory and antiviral responses following interaction with TLR 7 and 8. We have encapsulated ovalbumin (OVA) in the presence and absence of polyuridylic acid (poly-U) inside polylactide microparticles. In comparison to microparticles...
A small national study was carried out in England in 2003/2004 to ascertain the views of primary care trusts (PCTs) and general practitioners (GPs) on whether influenza immunisation should be extended to all people aged 50–64 years from the current recommendation of 65 years or more. Results showed that as many primary care trusts would be in favour, as would not be in favour. A similarly divided...
Three vaccination information leaflets (VIL) were evaluated in the province of Québec in 2002–2003 to examine their use by vaccinators (nurses and physicians), and their success in reaching parents of infants and toddlers. Data were collected from vaccinators and parents by postal survey. Reception of all of the VIL was higher among nurses (98%) than among physicians (39%). Only 14% of parents were...
“Helicobacter (H.) heilmannii” type 1 colonizes the human stomach. It has been shown to be identical to “Candidatus H. suis”, a Helicobacter species colonizing the stomach of more than 60% of slaughter pigs. This bacterium is, until now, not isolated in vitro. The effect of vaccination on “Candidatus H. suis” infection was studied in a mouse model. Mice were vaccinated intranasally or subcutaneously...
Mycobacterium bovis bacille Calmette Guerin vaccination protects against pulmonary tuberculosis in the United Kingdom but not in Malawi. We investigated whether a difference in the clonal T-cell response to BCG vaccination might account for this. The results of clonal analysis were compared to those obtained by skin testing and in a whole blood interferon gamma assay.Pre-vaccination antigen specific...
Attenuated antibody responses have been reported in preterm infants who received neonatal dexamethasone treatment. The duration of immunosuppression may extend into later infancy. This study assessed the immune response of former preterm infants to a single meningococcal serogroup C conjugate (MCC) immunisation given after infancy. A cohort of 49 toddlers born at less than 33 weeks’ gestation were...
Pacific children have had consistently evidenced low rates for routine childhood immunisations. Using the Pacific Islands Families: First 2 Years of Life cohort study, we investigated the immunisation rate of Pacific infants residing in New Zealand at 24-months postpartum. Full immunisation was reported for 89% of infants, substantially increased from the 53% found in the 1992 national survey and...
Following a number of mumps outbreaks in universities and colleges, the UK Health Protection Agency has suggested that it is appropriate to consider offering the MMR vaccine in these settings. However, little is known about the factors associated with uptake of the MMR jab or perceptions of risks/benefits of the vaccine among higher education students. The current study focused on a sample of students...
During an outbreak in a German day-care centre (DCC) caring for 100 children HAV vaccination was recommended for children, employees and household members of cases. A retrospective cohort study was done to evaluate vaccine uptake and identify possible risk factors for disease. Between 19 December 2004 and 30 January 2005 eight DCC children and seven household members fulfilled the case definition,...
We examined uptake of primary immunisations in infancy and the reasons given by mothers for either incompletely or not immunising their infants. We used data from the Millennium Cohort Study, a cohort of 18,819 infants born between September 2000 and January 2002 in the UK. 95.6% infants were reported to be fully immunised, 3.3% partially immunised and 1.1% unimmunised. Mothers most frequently cited...
This review considers possible reasons behind parents’ missed vaccination opportunities in the context of the latest immunisation coverage rates for England. Suboptimal uptake is not exclusive to measles, mumps and rubella (MMR). A substantial proportion of children also miss diphtheria, tetanus and polio vaccination. For MMR and diphtheria, tetanus and polio, uptake of primary plus booster immunisation...
This study sought to explore how parents respond to competing media messages about vaccine safety. Six focus groups with mothers of infants were shown television vignettes of typical pro- and anti-vaccination claims. Thematic analysis of transcripts was undertaken. Mothers expressed surprise and concern about alleged vaccine risks but quickly reinstated their support for vaccination by deference to...
Although previous studies have shown either no association between immunisation and SIDS or even a decreased risk of SIDS, adverse effects, including death, from immunisations continue to cause concern, especially when a new vaccine is introduced.A large case control study with immunisation data on 307 SIDS cases and 971 controls.SIDS cases were immunised less frequently and later than controls. Furthermore...
Notification trends from countries with well-established immunisation programs show increasing tetanus cases among the elderly, corresponding to seroepidemiologic data showing declining immunity with advanced age. We examined Australian trends in tetanus to review the likely value of routine funded immunisation at 65 years. Since 1993, 62% (36/58) of notifications, 44% (67/151) of hospitalisations...
Enhanced surveillance for invasive pneumococcal disease (IPD) has been ongoing in Western Australia since 1996. We describe the epidemiology of invasive pneumococcal disease in children aged <2 years between 1996 and 2005. Pneumococcal conjugate vaccine has been offered to Aboriginal children and other high-risk children since July 2001 and to all Australian children since January 2005. A total...
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