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We here studied the antibody response to a booster dose four years after the administration of one single dose of recombinant HB vaccine. Before receiving the booster dose, levels of protective antibodies (anti-HBs) were generally low and 24/41 (59%) individuals lacked detectable antibodies (<1 IU/L). Within 14 d of booster vaccination, 36/38 (95%) vaccinees showed levels of antibodies >100...
Since the beginning of the Italian program of immunization against hepatitis B, vaccine has been given to more than 9 million children, with an outstanding record of safety and efficacy. The coverage rate is globally around 94%, with differences between Northern and Southern regions, the latter having the lower acceptance rate. According to the National Surveillance System (SEIEVA), the incidence...
Notifications of acute icteric hepatitis B have declined since the introduction of vaccination but it is not clear whether the reservoir of infection and the proportion of adults who remain susceptible have also changed. This has been investigated by evaluation of serological evidence of infection and immunity, patient recall of vaccination and risk factors for exposure to hepatitis B in 2115 adult...
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