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Two candidate vaccines to prevent infection with human papillomavirus (HPV) Types 11 and 16 were studied in similar double-blind, placebo-controlled, dose-escalation trials. L1 virus-like particle (VLP) vaccines were made from recombinant L1 capsid protein of HPV11 or HPV16. Participants received 10, 20, 50, or 100μg of HPV11 L1 VLPs, 10, 40, or 80μg of HPV16 L1 VLPs, or placebo at Months 0, 2, and...
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