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DNA vaccines have been the subjects of much effort over the past decade due to their ability to induce broad-based immune responses and protection in various animal models of infectious and non-infectious diseases. In particular, influenza DNA vaccines have been well studied. This brief review highlights some of this early work that helped establish the DNA vaccine technology as a potential new mode...
Parenteral administration of microparticle encapsulated DNA elicits immune responses to the encoded antigens. Experiments were performed to test whether the addition of certain lipophilic agents to such formulations enhanced the activity of a beta-galactosidase (β-gal) DNA vaccine. Addition of either taurocholic acid (TA) or monomethoxy polyethylene-glycol-distearoylphosphatidylehanolamine (PEG-DSPE)...
Without going into the details of the devastation that human immunodeficiency virus (HIV) infection causes especially in the developing world, the best hope for changing the course of this epidemic is development of a safe, effective, accessible prophylactic HIV vaccine. While the inaccessibility of potentially neutralising epitopes on primary HIV isolates has hampered the development of envelope-based...
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