This study aims to evaluate the features of stone disease presenting in infancy and the outcome of ESWL treatment.Twenty-three babies with stone disease (18 boys &,5 girls) all under the age of one have been prospectively recorded in our database within the last year. All clinical and metabolic features of stone disease in this very young population including the short term outcome of ESWL treatment have been evaluated.Twenty three babies with a median age of 11 months have presented with stone disease and undergone ESWL treatment. There was no family history of urolithiasis. Most common presenting sign was microscopic haematuria. Of the 23 patients, 18 had bilateral and 5 had unilateral renal stone disease. Most had multiple stones. The total number of shocks per treatment ranged from 600 to 1400. The stone-free rate was 56 % three days after and 91 % 10 days after ESWL. The final stone-free rate was 96,3 % for pelvis stones (mean stone burden 27±20mm 2 ) and 84.7% for calyceal stones (mean stone burden 19±15mm 2 ).The stone analysis revealed cystine in 2, uric acid in one and calcium stones in 20. There were no failures except two patients with cystine stones who have undergone surgical intervention after failed ESWLStone disease in infants have favourable features such as high clearence rates following ESWL and rapid spontaneous dissolution with appropriate hydration and conservative follow-up. Success rate is high even in large stones with ESWL treatment in this age group.