This study was designed to compare the effects of a morning meal containing SugarLike, a low calorie sweetener, or sucrose on plasma glucose, insulin, and triglycerides. Eight subjects with type 2 diabetes were recruited. All of the subjects were being treated with diet and/or sulfonylurea medications; none were taking insulin. Subjects arrived fasting and after duplicate baseline blood samples were taken, breakfast was provided. Breakfasts containing equal volumes of either the low calorie sweetener or sucrose were consumed in a double-blind design in random order on different days. Following the meal, blood samples were taken every 15minutes over 2.5 hrs, to measure glucose, triglyceride, and insulin concentrations. Areas under the curve were calculated and a multivariate T 2 was used to test for differences between the two meals. There was a significant difference (p=0.04) between the meals in mean plasma measurements. Individual examination of analytes showed that glucose concentrations accounted for most (64%) of the difference. When the three variables were analyzed separately, glucose was significantly different (p=0.01), but the other analytes did not reach statistical significance. This study suggests that SugarLike, a new low calorie sweetener, causes less postprandial glycemia than sucrose in individuals with diabetes.