To examine the relationship between multiple lifestyle related diseases and inflammatory bowel disease (IBD), ICR mice were fed normal chow (CE-2), CE-2 with dextran sodium sulphate (DSS) in drinking water, a high fat diet (Quick Fat), or a fibre-free diet (AIN-76(-)). The plasma LDL/HDL cholesterol ratio was generally higher in the AIN-76 (-) and DSS groups. Shortening of the colon, an indicator of IBD, was prominent in the AIN-76(-) group. Damage of colon epithelial cells and layers was considerable in the DSS group, and was also observed in the Quick Fat and AIN-76(-) groups. Gram staining of caecal contents revealed that sporulation was promoted by DSS. The 16S rDNA amplicon sequencing of caecal contents showed that the Firmicutes/Bacterioidetes ratio (F/B) was considerably high in the AIN-76(-) group. In addition to Turicibacter and Bacteroides, Akkermansia muciniphila, which reportedly ameliorates obesity and increases the immune reaction, was high in the DSS group.