Journal of the Neurological Sciences

Items from 1 to 20 out of 32 results

article

The relationship between homocysteine, cognition and stroke subtypes in acute stroke

S.Y. Tay, E.R. Ampil, C.P.L.H. Chen, A.P. Auchus

Journal of the Neurological Sciences > 2006 > 250 > 1-2 > 58-61

Elevations in plasma homocysteine (Hcy) have been associated with an increased risk of stroke and dementia. The mechanisms underlying these associations remain poorly understood.This study examines the relationships between Hcy, cognition, and stroke subtype. We hypothesize that: 1) Hcy levels are inversely related to cognition, 2) Hcy levels are unrelated to stroke subtype, and 3) stroke subtype...

article

GABAA-receptor mRNA expression in the prefrontal and temporal cortex of ALS patients

Susanne Petri, Katja Kollewe, Claudia Grothe, Akira Hori, more

Journal of the Neurological Sciences > 2006 > 250 > 1-2 > 124-132

There is evidence that excitotoxic cell death is involved in the pathogenesis of amyotrophic lateral sclerosis (ALS). Electrophysiological and histological studies support the pathophysiological concept of an impaired inhibitory, namely GABAergic, control of the motoneurons in the cerebral cortex of ALS patients. Recently, pathological, neuropsychological and functional imaging data have challenged...

article

Two cases of spontaneous middle cerebral arterial dissection causing ischemic stroke

Jin Soo Lee, Oh Young Bang, Phil Hyu Lee, Byung Moon Kim, more

Journal of the Neurological Sciences > 2006 > 250 > 1-2 > 162-166

Spontaneous middle cerebral arterial dissection (MCAD) is a rare cause of ischemic stroke. We report two cases of isolated spontaneous MCAD causing ischemic stroke. MCAD should be considered when a young patient has a middle cerebral artery territory infarct with stenosis at the origin of the middle cerebral artery. We discuss noninvasive radiological techniques for the diagnosis of MCAD.

article

CSF orexin levels of Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal degeneration

Kenichi Yasui, Yuichi Inoue, Takashi Kanbayashi, Takashi Nomura, more

Journal of the Neurological Sciences > 2006 > 250 > 1-2 > 120-123

Excessive daytime sleepiness has been widely accepted as a common problem not only in Parkinson's disease (PD) but also in other related disorders. Lowered excretion of orexin A (hypocretin 1) into the cerebrospinal fluid (CSF) is known to play a pathological role in narcolepsy and secondary hypersomnia due to hypothalamic dysfunction. Although the levels of CSF orexin in PD have been previously examined,...

article

Reduction in the motor unit number estimate (MUNE) after cerebral infarction

Keisuke Arasaki, Osamu Igarashi, Yasumitsu Ichikawa, Toru Machida, more

Journal of the Neurological Sciences > 2006 > 250 > 1-2 > 27-32

Background: The mechanism of the decrease in motor unit number estimates (MUNEs) after cerebral infarction has not been studied systematically. We examined the relationship between the degree to which MUNEs decreased and the other clinical features of patients with the infarction. Methods: Using a multiple point stimulation technique, we obtained the MUNE of the hypothenar muscle group in 13 age-matched...

article

Oscillatory cerebral hemodynamics—the macro- vs. microvascular level

Matthias Reinhard, Elisabeth Wehrle-Wieland, Daniel Grabiak, Markus Roth, more

Journal of the Neurological Sciences > 2006 > 250 > 1-2 > 103-109

The phase shift between oscillations of blood pressure (BP) and Doppler middle cerebral artery flow velocity (MCAFV) reflects continuous cerebral autoregulatory action. It is not known whether a similar phase shift exists for cortical hemodynamics (‘microvascular level’) assessed by near infrared spectroscopy (NIRS) and what the effects are of pathological conditions. This study investigates the phase...

article

Comparison of regional cerebral blood flow in two subsets of subcortical ischemic vascular dementia: Statistical parametric mapping analysis of SPECT

Yong S. Shim, Dong-Won Yang, Beum-Saeng Kim, Young Min Shon, more

Journal of the Neurological Sciences > 2006 > 250 > 1-2 > 85-91

The brain imaging criteria for subcortical ischemic vascular dementia (SIVD), as proposed by Erkinjuntti, incorporated two clinical entities, the lacunar state and Binswanger's disease. However it has not been proven whether these two subtypes of SIVD have common pathophysiological features. This study investigated the changes of regional cerebral blood flow (CBF) in the two subsets of SIVD to establish...

article

Intrafamilial phenotypic and genetic heterogeneity of dystonia

Vladimir S. Kostić, Marina Svetel, Kemal Kabakci, Aleksandar Ristić, more

Journal of the Neurological Sciences > 2006 > 250 > 1-2 > 92-96

Most cases of early-onset primary torsion dystonia are caused by the same 3-bp (GAG) deletion in the DYT1 gene. We describe a large Serbian family with significant intrafamilial variability of the DYT1 phenotype, from asymptomatic carrier status to late-onset focal, and generalized jerky dystonia. Seven mutation carriers (six proven by direct analysis and one by inferred haplotype) were identified,...

article

Acute encephalopathy with refractory status epilepticus: Bilateral mesial temporal and claustral lesions, associated with a peripheral marker of oxidative DNA damage

Takashi Shiihara, Mitsuhiro Kato, Takashi Ichiyama, Yukitoshi Takahashi, more

Journal of the Neurological Sciences > 2006 > 250 > 1-2 > 159-161

We describe a 12-year-old girl, who had been medicated with theophylline for bronchial asthma and developed acute encephalopathy with refractory status epilepticus, showing bilateral mesial temporal and claustral lesions, which were evident on fluid-attenuated inversion recovery images, obtained with 1.5 T magnetic resonance imaging. To date, oxidative stress has been implicated in aging or various...

article

Cambodian founder effect for spinocerebellar ataxia type 3 (Machado–Joseph disease)

Suman Jayadev, Sara Michelson, Hillary Lipe, Thomas Bird

Journal of the Neurological Sciences > 2006 > 250 > 1-2 > 110-113

Four families from the same region of Cambodia immigrated to the Pacific Northwest of the United States. All four families have been discovered to have spinocerebellar ataxia type 3 (SCA 3; Machado–Joseph disease) with a similar clinical phenotype. CAG repeat expansions in the ATXN3 gene range from 72 to 77. Mean age of onset has varied from 19 to 44 years and mean age at death of 4 individuals has...

article

Evaluating a formal evidence-based clinical practice curriculum in a neurology residency program

J.G. Burneo, M.E. Jenkins, M. Bussière

Journal of the Neurological Sciences > 2006 > 250 > 1-2 > 10-19

Since 1998, the University of Western Ontario Evidence-Based Neurology Programme has been fostering life-long self-teaching, self-evaluation, and promoting improvement of the care of neurological patients by teaching neurology residents to practice Evidence-Based Clinical Practice (EBCP).Using a questionnaire/survey we evaluated participation during EBCP sessions and the applicability of EBCP to current...

article

A case of isolated and transient splenial lesion of the corpus callosum associated with disseminated Staphylococcus aureus infection

Ji Man Hong, In Soo Joo

Journal of the Neurological Sciences > 2006 > 250 > 1-2 > 156-158

We report a 20-year-old man who presented with temporary encephalopathy. Serial brain MRI revealed an isolated and transient splenial lesion of the corpus callosum (SCC). He was subsequently diagnosed with septic metastasis of Staphylococcus aureus (S. aureus) involving both lungs and multiple joints; however, there was no indication of S. aureus involvement of the meninges or brain parenchyma in...

article

Mutation impact on dysferlin inferred from database analysis and computer-based structural predictions

Christian Therrien, Dubravka Dodig, George Karpati, Michael Sinnreich

Journal of the Neurological Sciences > 2006 > 250 > 1-2 > 71-78

Dysferlin is a large sarcolemmal protein implicated in the repair of surface membrane tears in muscle cells. Mutations in dysferlin result in limb girdle muscular dystrophy type 2B and Miyoshi myopathy. Using a cDNA based approach we identified eight new pathogenic dysferlin alleles. To better understand how missense mutations could lead to reduced or absent dysferlin expression levels, we mapped...

article

Predictors of delay in the diagnosis and clinical trial entry of amyotrophic lateral sclerosis patients: A population-based study

Stefano Zoccolella, Ettore Beghi, Guerrino Palagano, Angela Fraddosio, more

Journal of the Neurological Sciences > 2006 > 250 > 1-2 > 45-49

The El Escorial and the revised Airlie House diagnostic criteria for amyotrophic lateral sclerosis (ALS) were introduced to select patients for clinical trials. Heterogeneity of clinical presentation at onset and delay in diagnosis may decrease the likelihood for trial entry.Identify risk factors for delay in the diagnosis and trial exclusion.ALS incident cases were identified with El Escorial (EEC)...

article

Normal anatomy of the developing fetal brain. Ex vivo anatomical–magnetic resonance imaging correlation

Mariana Bendersky, Patricia L. Musolino, Carlos Rugilo, Gustavo Schuster, more

Journal of the Neurological Sciences > 2006 > 250 > 1-2 > 20-26

Fetal brain Magnetic Resonance Imaging (MRI) is a new technique of growing interest, with a high potential to detect prenatal central nervous system abnormalities. This requires an accurate knowledge of the normal morphological sequence of brain development. In this paper we studied the cortical development of post-mortem normal fetal brains, correlating MRI estimations of fetal age with in vitro...

article

Cold-induced sweating syndrome A report of two cases and demonstration of genetic heterogeneity

A.F. Hahn, D.L. Jones, P.M. Knappskog, H. Boman, more

Journal of the Neurological Sciences > 2006 > 250 > 1-2 > 62-70

To characterize the specific autonomic disturbances underlying the cold-induced sweating syndrome (CISS), and to describe a novel genetic variant of this rare recessive disorder. The two not previously reported patients had similar dysmorphic features: abnormal facial appearance, high arched palate, low set rotated ears, flexion deformities of elbows and fingers and scoliosis. Most noticeable were...

article

Clinical characteristics of Restless legs syndrome in patients with Parkinson's disease

Takashi Nomura, Yuichi Inoue, Kenji Nakashima

Journal of the Neurological Sciences > 2006 > 250 > 1-2 > 39-44

To assess the characteristics, clinical significance and pathology of Restless legs syndrome (RLS) in patients with Parkinson's disease (PD), we studied clinical backgrounds, RLS symptoms, polysomnographic (PSG) variables and therapeutic outcomes in 13 PD patients with RLS (pRLS), and compared them with those of 22 idiopathic RLS patients (iRLS). In all but one pRLS patient, RLS symptoms arose within...

article

Ipsilateral silent period: A marker of callosal conduction abnormality in early relapsing–remitting multiple sclerosis?

Patrick Jung, Astrid Beyerle, Marek Humpich, Tobias Neumann-Haefelin, more

Journal of the Neurological Sciences > 2006 > 250 > 1-2 > 133-139

The corpus callosum (CC) is commonly affected in multiple sclerosis (MS). The ipsilateral silent period (iSP) is a putative electrophysiological marker of callosal demyelination. The purpose of this study was to re-assess, under recently established optimised protocol conditions [Jung P., Ziemann U. Differences of the ipsilateral silent period in small hand muscles. Muscle Nerve in press.], its diagnostic...

article

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Journal of the Neurological Sciences > 2006 > 250 > 1-2 > 170-171

article

Ubiquitin-positive frontotemporal lobar degeneration presenting with progressive Gogi (word-meaning) aphasia. A neuropsychological, radiological and pathological evaluation of a Japanese semantic dementia patient

Yasuhisa Sakurai, Kuniaki Tsuchiya, Tatsuro Oda, Koji Hori, more

Journal of the Neurological Sciences > 2006 > 250 > 1-2 > 3-9

A patient with progressive anomia and alexia with agraphia for kanji (Japanese morphograms) is described. The patient showed a deficit in single-word comprehension and on-reading (a type of reading that conveys phonetic value) dominance in kanji reading, i.e. on-preceding (pronouncing first with on-reading, irrespective of its preferred reading) and kun-deletion (inability to recall and recognize...

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250
Year:
2006

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Keywords

CORPUS CALLOSUM (2)
DEMENTIA WITH LEWY BODIES (2)
PARKINSON'S DISEASE (2)
STROKE (2)
8-HYDROXYDEOXYGUANOSINE (1)
ACTIVIN (1)
ACUTE ENCEPHALOPATHY (1)
AIRLIE HOUSE CRITERIA (1)
ALZHEIMER'S DISEASE (1)
AMYOTROPHIC LATERAL SCLEROSIS (1)
AMYOTROPHIC LATERALS SCLEROSIS (1)
ANATOMY (1)
ANGIOGRAPHY (1)
ANTI-YO (1)
ATAXIA (1)
BINSWANGER'S DISEASE (1)
CAMBODIA (1)
CAMEROON (1)
CANCER (1)
CAROTID ARTERY STENOSIS (1)
CENTRAL MOTOR CONDUCTION TIME (1)
CENTRAL NERVOUS SYSTEM (1)
CEREBRAL AUTOREGULATION (1)
CEREBRAL BLOOD FLOW (1)
CEREBRAL CORTEX (1)
CEREBRAL INFARCTION (1)
CEREBROSPINAL FLUID (1)
CEREBROVASCULAR (1)
CISS (1)
CISS2 (1)
CLAUSTRUM (1)
CLC (1)
CLCF1 (1)
CLF (1)
CLINICAL TRIALS (1)
CNS (1)
COGNITION (1)
COLD-INDUCED SWEATING (1)
COMMUNITY-DWELLING (1)
COMPUTER BASED STRUCTURAL PREDICTIONS (1)
CORTICOBASAL DEGENERATION (1)
CRITICAL DISEASE (1)
CRLF1 (1)
DEMENTIA (1)
DEMYELINATION (1)
DEVELOPMENT (1)
DIAGNOSTIC DELAY (1)
DIFFERENTIAL DIAGNOSIS (1)
DIFFUSION-WEIGHTED IMAGING (1)
DISSECTION (1)
DOPAMINE AGONIST (1)
DOPPLER, TRANSCRANIAL (1)
DYSFERLIN (1)
DYT1 DYSTONIA – PHENOTYPIC VARIABILITY (1)
EL ESCORIAL CRITERIA (1)
ELDERLY (1)
EPIDEMIOLOGY (1)
EVIDENCE-BASED CLINICAL PRACTICE (1)
EXCESSIVE DAYTIME SLEEPINESS (1)
EXTRAMOTOR BRAIN REGIONS (1)
FAMILIAL MADRAS MOTOR NEURON DISEASE (1)
FETAL BRAIN (1)
FOLLISTATIN (1)
FRONTOTEMPORAL DEMENTIA (1)
GABAA-RECEPTORS (1)
GOGI APHASIA (1)
HAND WEAKNESS (1)
HOMOCYSTEINE (1)
HYPOTHENAR MUSCLE GROUP (1)
IN SITU HYBRIDIZATION HISTOCHEMISTRY (1)
INCIDENCE (1)
INHIBITORY NEUROTRANSMISSION (1)
INTERNATIONAL RESTLESS LEGS SYNDROME STUDY GROUP SEVERITY SCALE OF RLS (1)
INVASIVE THYMOMA (1)
IPSILATERAL SILENT PERIOD (1)
LACUNE (1)
LIMB-GIRDLE MUSCULAR DYSTROPHY (1)
LIMBIC ENCEPHALITIS (1)
MACHADO–JOSEPH DISEASE (1)
MAGNETIC RESONANCE IMAGING (1)
MENINGITIS (1)
MIDDLE CEREBRAL ARTERY (1)
MINI-MENTAL STATE EXAMINATION (1)
MIYOSHI MYOPATHY (1)
MMSE (1)
MORTALITY (1)
MOTOR UNIT NUMBER ESTIMATE (MUNE) (1)
MRI (1)
MUTATION ANALYSIS (1)
MYOPATHY (1)
NEAR INFRARED (1)
NEUROGENETICS (1)
NEUROLOGICAL DISEASES (1)
NEUROLOGY (1)
NEUROPATHY (1)
OCULAR COHERENCE TOMOGRAPHY (1)
OPTIC NEURITIS (1)
OSCILLATIONS (1)
OXIDATIVE STRESS (1)
PARANEOPLASTIC (1)
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Journal of the Neurological Sciences

The relationship between homocysteine, cognition and stroke subtypes in acute stroke

GABAA-receptor mRNA expression in the prefrontal and temporal cortex of ALS patients

Two cases of spontaneous middle cerebral arterial dissection causing ischemic stroke

CSF orexin levels of Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal degeneration

Reduction in the motor unit number estimate (MUNE) after cerebral infarction

Oscillatory cerebral hemodynamics—the macro- vs. microvascular level

Comparison of regional cerebral blood flow in two subsets of subcortical ischemic vascular dementia: Statistical parametric mapping analysis of SPECT

Intrafamilial phenotypic and genetic heterogeneity of dystonia

Acute encephalopathy with refractory status epilepticus: Bilateral mesial temporal and claustral lesions, associated with a peripheral marker of oxidative DNA damage

Cambodian founder effect for spinocerebellar ataxia type 3 (Machado–Joseph disease)

Evaluating a formal evidence-based clinical practice curriculum in a neurology residency program

A case of isolated and transient splenial lesion of the corpus callosum associated with disseminated Staphylococcus aureus infection

Mutation impact on dysferlin inferred from database analysis and computer-based structural predictions

Predictors of delay in the diagnosis and clinical trial entry of amyotrophic lateral sclerosis patients: A population-based study

Normal anatomy of the developing fetal brain. Ex vivo anatomical–magnetic resonance imaging correlation

Cold-induced sweating syndrome A report of two cases and demonstration of genetic heterogeneity

Clinical characteristics of Restless legs syndrome in patients with Parkinson's disease

Ipsilateral silent period: A marker of callosal conduction abnormality in early relapsing–remitting multiple sclerosis?

Calendar of Events

Ubiquitin-positive frontotemporal lobar degeneration presenting with progressive Gogi (word-meaning) aphasia. A neuropsychological, radiological and pathological evaluation of a Japanese semantic dementia patient

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