We have studied the magnetic, structural and transport properties of sputtered Fe/Cr(1 1 0) superlattices as a function of the Ar pressure during the deposition. A systematic increase in the roughness is induced, as shown by low-angle X-ray diffraction measurements. As the Ar pressure becomes higher, it is also found an increase in the electrical resistivity, related with internal stresses, and a reduction in the antiferromagnetic coupling between the layers. However, the giant magnetoresistance (Δρ), normalized by the antiferromagnetically coupled fraction of the sample, increases for the highest Ar pressures, implying that the spin-dependent scattering mechanisms are enhanced by roughening of the interfaces.