Anterior knee pain is a common ailment of the knee. Both open (single joint) and closed (multiple joint) kinetic chain exercises have been recommended in the treatment of this condition. The aim of this study was to compare the efficacy of single joint quadriceps exercises (SJQE) with multiple joint quadriceps exercises (MJQE) in the rehabilitation of patients with anterior knee pain. Forty five male subjects with anterior knee pain were randomly assigned into one of three groups. Group 1: SJQE performed seated knee extension exercises, group 2: MJQE performed seated leg press exercises and group 3 was the control group receiving no treatment. Both exercise groups trained for 4 sets with 13 repetitions (maximum) three times per week for 6 weeks. The loads lifted were adjusted according to the DAPRE principle. Pain scores (visual analogue scale) during isometric quadriceps contraction and a single step ascent and descent, isometric quadriceps strength and a functional questionnaire (Kujala questionnaire score) were evaluated on initial examination and at the end of the 6 week treatment period. Both exercise groups demonstrated statistically significant decreases in pain, and increased quadriceps strength and functional performance compared with the control group (p<0.003). The control group had a significant reduction in functionality p=0.03. The subjects in the MJQE group showed greater improvements compared to those in the SJQE group but the differences were not statistically significant. This study demonstrates that both single and multiple joint quadriceps exercises can significantly improve anterior knee pain patient's pain, strength and functional status over a 6 week training period, but neither exercise protocol was statistically superior.