Synthetic biology provides a means for articulating concepts into new products [1]. Its toolbox is extensive, including the ability to create synthetic genomes and tailor their regulation. Early successes augmented cells’ biosynthetic capacities and rewired their regulation, transforming our ability to produce fully functional therapeutic proteins at high yield. Also, the theoretical formalisms of metabolic engineering provided a basis for optimally routing its biochemical flux. These activities focused largely on the cell's intracellular biochemical network and relied less on molecular cues from its immediate surroundings. Quorum sensing (QS) has enabled a reexamination of metabolic flux and regulation by hardwiring population-scale biological function to extracellular cues. Regulatory and fabrication modules are feasible owing to a few relatively simple QS signal transduction cascades. QS now provides a means to create entirely new products and processes that leverage community coordinated behaviors. Indeed, the intersection of QS and synthetic biology has expanded the biotechnology toolbox and is just beginning to yield new promising outcomes.