Wheat straws ash has been utilized as a silica source for the synthesis of NaY zeolite. The characteristics and performance of NaY as adsorbent for attraction of doxycycline (DC) pollutant were evaluated. The adsorption behavior of DCNaY system under different batch variables including solution pH (2–12), contact time (0–24 h), and initial DC concentration (40–120 mg/L) was also illustrated. The Langmuir model showed well representation for isotherm data, with maximum equilibrium uptakes of 252.12, 258.97, and 269.75 mg/g at 30, 40, and 50 °C, respectively. DC uptakes versus contact time data followed a pseudo-second order kinetic model. Endothermic and spontaneous natures were confirmed for studied system. NaY zeolite with a surface area of 657.44 m2/g and pore volume of 0.341 cm3/g could be an efficient adsorbent for treatment of antibiotic pollutants in wastewaters.