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DNA polymerase λ (Pol λ) is a DNA polymerase β (Pol β)-like enzyme with both DNA synthetic and 5′-deoxyribose-5′-phosphate lyase domains. Recent biochemical studies implicated Pol λ as a backup enzyme to Pol β in the mammalian base excision repair (BER) pathway. To examine the interrelationship between Pol λ and Pol β in BER of DNA damage in living cells, we disrupted the genes for both enzymes either...
The mammalian family X DNA polymerases (DNA polymerases β, λ, μ, and TdT) contribute to base excision repair and double-strand break repair by virtue of their ability to fill short gaps in DNA. Structural information now exists for all four of these enzymes, making this the first mammalian polymerase family whose structural portrait is complete. Here we consider how distinctive structural features...
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