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The cellular prion protein is expressed in almost all tissues, including the central nervous system and lymphoid tissues. To investigate the effects of the prion protein in lymphoid cells and spleen structure formation, we used prion protein-deficient (Prnp0/0) Zürich I mice generated by inactivation of the Prnp gene. Prnp0/0 mice had decreased lymphocytes, in particular, CD4 T cells and lymphoid...
We have previously demonstrated that prion protein-deficient (Prnp0/0) Zürich I mice display impaired T zone structure resulting from decreased splenic expression of the T cell homing chemokines, CCL19 and CCL21. Prions are transported to, and colonise in, the secondary lymphoid tissues. Therefore, in order to investigate how scrapie infection affects the splenic white pulp structure, we infected...
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