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The human E. coli heat-stable enterotoxin (ST h , amino acid sequence N 1 SSNYCCELCCNPACTGCY 19 ) binds specifically to the guanylate cyclase C (GC-C) receptor, which is present in high density on the apical surface of normal intestinal epithelial cells as well as on the surface of human colon cancer cells. Analogs of ST h are currently being used as vectors targeting...
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