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16α-[ 18 F]Fluoro-17β-estradiol ([ 18 F]FES) and various derivatives can be used to image noninvasively the expression of estrogen receptors in breast cancer. A high specific activity is required for successful visualization of ER expression in vivo, particularly for small animal imaging. We describe a simple method for effective specific activity (ESA) measurements of ER-binding ligands...
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